Saunders Respiratory Practice

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A client taking isoniazid reports numbness in extremities. What is this an indication of?

Allergic reaction
Peripheral neuritis
Drug resistance
Medication overdose

The correct answer is: Peripheral neuritis

The reporting of numbness in the extremities by a client taking isoniazid is indicative of peripheral neuritis. Isoniazid, a medication used primarily to treat tuberculosis, can interfere with the metabolism of pyridoxine (vitamin B6) in the body. This interference can lead to a deficiency in B6, which is essential for proper nerve function. When levels of this vitamin drop, patients may experience symptoms of peripheral neuropathy, including numbness, tingling, and weakness in the hands and feet. Monitoring for these side effects is crucial when prescribing isoniazid, and in many cases, patients are also given pyridoxine supplementation to prevent this complication. Recognizing peripheral neuritis allows for timely intervention, which can help avoid further neurological damage and improve the patient's overall quality of life during tuberculosis treatment.